Secondary endpoint: Composite of all-cause mortality, recurrent infarction, and stroke within 30 days of randomization.Ī total of 365 patients were randomized to an invasive strategy (n = 182) or conservative treatment (n = 183). Primary endpoint: Infarct size as determined by technetium sestamibi scintigraphy (SPECT) performed 5-10 days after randomization. Following the revascularization procedure, patients were continued on clopidogrel 75 mg/day for at least 1 month To either the invasive arm, consisting of coronary angiography with or without PCI and abciximab), or conventional medical In this study, AMI patients were treated with clopidogrel (300-600 mg), aspirin (500 mg), and heparin (70 U/kg) and were randomized Recent percutaneous coronary intervention (PCI) (Those with the following characteristics were excluded from the study: Patients were enrolled if they presented 12-48 hours following chest pain onset. Is associated with a reduction of infarct size in patients with AMI presenting > 12 hours after symptom onset.ĪMI was defined as chest pain lasting ≥ 20 minutes and ST-segment elevation or new pathological Q-waves. The Beyond 12 Hours Reperfusion Alternative Evaluation (BRAVE-2) trial was designed to assess whether an invasive strategy The value of an acute invasive treatment in these patients. Although availableĬlinical evidence discourages the use of thrombolytic therapy in this setting, no randomized trials have actually assessed Therefore, current guidelines do not recommend reperfusion treatment in these patients. Previous trials with thrombolytic agents have shown little or no benefit of attempting coronary reperfusion within It does not store any personal data.Presenter: Adnan Kastrati, MD, Deutsches Herzzentrum (Munich, Germany)Ī large proportion of acute myocardial infarction (AMI) patients present to the emergency room > 12 hours after the initiation The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. Our children and staff have been encouraged to be brave this week and to step out of their comfort zones. It’s about finding positive ways to deal with things that might be difficult, overcoming physical and mental challenges and looking after yourself. Being brave means different things to different people at different times and it isn’t about coping alone or holding things in. Life is full of challenges and includes taking small brave steps everyday whatever your age. They also thought about things they have done that are brave such as standing up in front of others, trying something new or talking to someone about something that worries them. The children all across the school, from Nursery to Year 8, were asked to consider what Bravery is: feeling fear and being vulnerable, but doing something despite the fear or risk (though not unsafe risks). We all have positive and negative feelings and good mental health means also experiencing negative emotions. Sometimes we are mentally happy, confident and carefree and sometimes we feel down, stressed, worried and scared. In our assembly at the start of the week the children were told that as well as physical health we all have mental health – it is our feelings, emotions, thinking and moods. Our theme for this fortnight is Clean Air and Clean Mind and we will be thinking about how pollution can affect both our bodies and our minds however, this week we have been focusing on our minds as we acknowledge and support Place2be’s Children’s Mental Health Week. However, the theme also allowed us to consider how we take responsibility for other areas of our lives. We’ve had Taking Responsibility, where our children were able to think about how we can take responsibility for our planet. Our themes of the week for this term have been focused on the topic of Planet Earth. Self-Esteem, Resilience and Mental Health.
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